An optically resolved crystal of thiomalate: (S)-1-phenylethanaminium (R)-thiomalate

Treatment of Filariasis by Lithium Antimony Thiomalate

In the coastal areas of southern districts of Madras presidency filariasis is very frequently met with and is commonly seen in an endemic form akin to malaria. The disease though not responsible for mortality as much as malaria ranks equally with it in causing hideous and permanent disfiguration and suffering to the inhabitants of these areas. A general practitioner in these rural areas finds f...

Free thiomalate levels in rheumatoid arthritis.

Crystal structure of (R)-N-benzyl-1-phenylethanaminium (R)-4-chloro­mandelate

The absolute configuration of the title mol-ecular salt, C15H18N(+)·C8H6ClO3 (-), has been confirmed by resonant scattering. In the (R)-N-benzyl-1-phenyl-ethyl-ammonium cation, the phenyl rings are inclined to one another by 44.65 (7)°. In the crystal, the (R)-4-chloro-mandelate anions are linked via O-H⋯O hydrogen bonds and bridged by N-H⋯O hydrogen bonds involving the cations, forming chains ...

Gold sodium thiomalate activates latent human leukocyte collagenase.

Gold sodium thiomalate, a drug used widely in the therapy of rheumatoid arthritis, was found to be an activator of latent human polymorphonuclear leukocyte collagenase. The activation was demonstrated by two distinct and independent collagenase assays: by recording with a spectrophotometer at 227 nm the enzyme-induced increase in ultraviolet difference absorbance of native type I collagen conne...

Effect of gold thiomalate on cell proliferation and collagen synthesis of synovial cells in culture.

Human synovial cells from cases of rheumatoid and osteoarthritis were cultured and at their 3-5 passages, were treated with gold thiomalate. At early-log phase gold thiomalate arrested the proliferation of cells. However, at confluent state shere was a slight proliferation of synovial cells. This was followed by an increase in prolyl hydroxylase, collagen and protein synthesis, indicating that ...